Advanced Drug Design and Development: A Medicinal Chemistry by P N Kourounakis

By P N Kourounakis

The dep. of Pharmaceutical-Medicinal Chemistry, university of Pharmacy, Aristotelian collage of Thessaloniki, organizes, any other 12 months, a graduate seminar in complex medicinal chemistry, with overseas participation, in Thessaloniki. the aim of this seminar is to aid younger and impressive pharmaceutical scientists during this box through updating their wisdom and informing them concerning the new tendencies in our technology, throughout the shows of popular invited audio system. it's also aimed to create a discussion board for trade of principles in medicinal chemistry, in a unique casual surroundings, bringinginternationally famous medicinal chemists towards their Greek colleagues. the various invited audio system during this sequence of seminars are: A.H.Beckett, A.Benakis, N.Bodor, D.D.Breimer, J.Caldwell, R.Ganellin, J.Gorrod, R.Franke, H.Kappus, P.Krogsgaard-Larsen, A.Makriyiannis, J.Seydel, H.Sies, J.Tollenaere and W.Wiegrebe.

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Advanced Drug Design and Development: A Medicinal Chemistry Approach

The dept of Pharmaceutical-Medicinal Chemistry, institution of Pharmacy, Aristotelian collage of Thessaloniki, organizes, some other 12 months, a graduate seminar in complex medicinal chemistry, with foreign participation, in Thessaloniki. the aim of this seminar is to assist younger and impressive pharmaceutical scientists during this box through updating their wisdom and informing them concerning the new traits in our technology, during the displays of well known invited audio system.

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And Weiss, S. (1985) Nature, 317, 717. D. G. (1989) J. , 53, 273. T. H. (1990) Eur. J. , 179, 479. , Bockaert, J. and Sladeczek, F. (1990) Trends Pharmacol. , 11, 508. , le Peuch, C. J. (1990) Neurosci. , 109, 146. L. F. (1988) J. Med. , 31, 2057. A. and Costa, E. (eds) (1989) in Allosteric Modulation of Amino Acid Recaptors: Therapeutic Implications, Raven Press, New York. CHAP. J. , 47, 1785. L. and Singer, W. , 11, 290. [] Lodge, D. M. , 11, 81. E. (1991) Biochem. , 41, 9. [] Lodge, D. M. (1990) Trends Pharmacol.

5). Like O,5-di-Me-THPO, O-propargyl-THPO shows higher M1 selectivity than, for example, arecoline, as indicated by their higher M2-M1 indices. The partial muscarinic agonists O,5-di-Me-THPO and O-propargyl-THPO (Fig. 5) have been tested pharmacologically in animal models. So far, vasodepressor, antinociceptive and anticonvulsant effects of arecoline and a series of isoxazole bioisosteres in anaesthetized rats gave parallel log doseresponse curves, and the order of potency of the compounds in this test system was identical with that measured in the guinea-pig ileum preparation, arecoline being the most potent compound, followed by O,5-di-Me-THPO and O-propargylTHPO.

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