By Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect
A concise one-stop-practical reference for a few of the physicians facing fungal infections, Antifungal remedy appeals to infectious sickness physicians, transplant surgeons, dermatologists, and intensivists, in addition to easy scientists and pharmaceutical corporation researchers drawn to the nation of antifungal remedy. This publication presents a finished, up to date review of the pertinent concerns referring to antifungal therapy. Divided into 4 interrelated sections for a cohesive dialogue covers:
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Approximately 50% of Trichosporon infections was determined to be disseminated, involving two or more organs with or without fungemia. 30 COSTA AND ALEXANDER Pneumocystis Pneumocystis pneumonia (PCP), due to P. jiroveci (previously P. carinii f. sp. hominis), remains one of the most feared complications of immunosuppression due to its signiﬁcant morbidity and mortality (439,440). Though the genus Pneumocystis has been known for years, taxonomic assignment of Pneumocystis has placed it with either fungi or protozoa, with phylogenetic data and characteristics that would lend credence to having it belong to either (441).
Malassezia folliculitis, due to M. furfur or M. pachydermatis, has been reported in heart transplant, kidney transplant, and BMT recipients (418–421). The rash can present as an acneiform eruption or as folliculitis with a papular or papular-pustular appearance. Fever may precede the rash in BMT recipients (278,420,421). Malassezia, both M. furfur and M. pachydermatis, has been implicated in fungemia in adults, children, and infants receiving intravenous lipids or with prolonged catheterization (410,412,413,422,423).
Exserohilum Exserohilum may also cause infections in both immunocompromised and immunocompetent hosts (91,232–235). Reported cases are mainly from warm tropical and subtropical regions of the world. Patients typically present with infections of the skin and soft tissue, cornea, paranasal sinuses including allergic fungal sinusitis, lungs, bone, and brain. Species implicated include E. rostratum, E. longirostratum, and E. mcginnisii. Corneal infection is usually secondary to trauma, and none of the reported cases occurred in immunosuppressed individuals.