By Larry Bauer
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Extra info for Applied Clinical Pharmacokinetics
Pharmacokinetics of salicylate elimination in man. J Pharm Sci. 1965;54(7):959–967. 4. Bowdle TA, Patel IH, Levy RH, et al. Valproic acid dosage and plasma protein binding and clearance. Clin Pharmacol Ther. 1980;28(4):486–492. 5. Lima JJ, Boudoulas H, Blanford M. Concentration-dependence of disopyramide binding to plasma protein and its inﬂuence on kinetics and dynamics. J Pharmacol Exp Ther. 1981; 219(3):741–747. 6. Bertilsson L, Höjer B, Tybring G, et al. Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique.
ONE-COMPARTMENT MODEL EQUATIONS FOR LINEAR PHARMACOKINETICS 29 FIGURE 2-1 Using compartment models, the body can be represented as a series of discrete sections. The simplest model is the one-compartment model which depicts the body as one large container where drug distribution between blood and tissues occurs instantaneously. Drug is introduced into the compartment by infusion (ko), absorption (ka), or IV bolus; distributes immediately into a volume of distribution (V); and is removed from the body via metabolism and elimination via the elimination rate constant (ke).
2. Ludden TM, Allen JP, Valutsky WA, et al. Individualization of phenytoin dosage regimens. Clin Pharmacol Ther. 1977;21(3):287–293. 3. Levy G. Pharmacokinetics of salicylate elimination in man. J Pharm Sci. 1965;54(7):959–967. 4. Bowdle TA, Patel IH, Levy RH, et al. Valproic acid dosage and plasma protein binding and clearance. Clin Pharmacol Ther. 1980;28(4):486–492. 5. Lima JJ, Boudoulas H, Blanford M. Concentration-dependence of disopyramide binding to plasma protein and its inﬂuence on kinetics and dynamics.