Autonomic and Enteric Ganglia: Transmission and Its by Alexander G. Karczmar (auth.), Alexander G. Karczmar, Kyozo

By Alexander G. Karczmar (auth.), Alexander G. Karczmar, Kyozo Koketsu, Syogoro Nishi (eds.)

In the early Nineteen Sixties, Dr. Alexander G. Karczmar, Professor of Pharmacology and Experimental Therapeutics on the Stritch college of medication of the scientific middle at Loyola college of Chicago, used to be faced with a undeniable technical challenge touching on his stories of synaptic transmission by way of microelectrode equipment. He idea that the matter could be resolved if he may well curiosity a microelectrode professional similar to Dr. Kyozo Koketsu in his reviews. Dr. Koketsu was once a prior member of the college of the Kurume collage college of medication who as a learn Fellow on the Australian nationwide college had helped Sir John Eccles, subse­ quently a Nobel Prize winner, in constructing microelectrode approaches. After additional contemplating the problem, Dr. Karczmar used to be pleasantly sur­ prised to find that by way of twist of fate Dr. Koketsu was once his neighbor, serving at the moment as a learn Professor on the Neuropsychiatry Institute of the collage of Illinois, university of drugs of Chicago. This used to be the start of an extended dating, as Dr. Koketsu joined Dr. Karczmar at Loyola as Professor of Pharmacology and Therapeutics and Director of the Neurophysiology Laboratory on the Stritch university of drugs. It was once no longer lengthy earlier than Dr. Syogoro Nishi-Dr. Koketsu's former colleague at the college of drugs at Kurume collage, and at the moment a study Fellow in Neurophysiology on the Rockefeller Institute in big apple­ joined Drs. Koketsu and Karczmar at Loyola. even if in due time Drs.

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Soc. Exp. Bioi. 29:1945-1956 (1970). : Slow potentials in sympathetic ganglia, in: Electrohysiological Approaches to Human Cognitive Processing (R Galambos and S. A. ), pp. 236-239, Neurosciences Research Program Bulletin, Vol. 20, MIT Press Journals, Cambridge, Massachusetts (1981). : Concomitant changes in formaldehyde-induced fluorescence of dopamine interneurons and in slow inhibitory postsynaptic potentials of the rabbit superior cervical ganglion, induced by stimulation of the preganglionic nerve or by a muscarinic agent.

Interestingly, however, anyone preganglionic nerve fiber synapsed with several neurons in a cluster, though not necessarily with closely adjacent cells. Thus, the ganglion provides a certain degree of divergence of autonomic outflow but no convergence, since each neuron, in the adult, is singly innervated. , 1971) on the ganglion cells in the amphibian heart. In addition to describing the electrophysiological characteristics of these neurons, these authors correlated, with amazing preci- 30 I. History and Anatomical Bases sian, the exquisite detail seen in the living neuron by means of differential interference contrast optics with the electron-microscopic features of the same neuron.

Proc. Fed. Am. Soc. Exp. BioI. 28:101-112 (1969). : Characteristics of the slow inhibitory postsynaptic potential of bullfrog sympathetic ganglion cells. Life Sci. 6:1827-1836 (1967). : Studies on pupillary reactions in Tetrapods. J. Pharmacol. Exp. Ther. 36:179-,-183 (1929). : Studies on the synergism and antagonism of drugs. I. The non-parasympathetic antagonism between atropine and the miotic alkaloids. J. Pharmacol. Exp. Ther. 46:395405 (1932). , and Karczmar, A. : Contribution to the study of the mechanism of action of cholinesterase inhibitors.

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