By Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese
Biocatalysis is swiftly evolving right into a key know-how for the invention and construction of chemical substances, in particular within the pharmaceutical undefined, the place excessive yielding chemo-, regio-, and enantioselective reactions are severe. Taking the newest breakthroughs in genomics and proteomics under consideration, Biocatalysis for the Pharmaceutical Industry concisely but comprehensively discusses the fashionable software of biocatalysis to drug discovery, improvement, and production. Written via a workforce of major specialists, the publication bargains deep perception into this leading edge box.
- Covers quite a lot of themes in a scientific demeanour with an emphasis on business purposes
- Provides a radical creation to the newest biocatalysts, sleek expression hosts, state of the art directed evolution, excessive throughput screening, and bioprocess engineering
- Addresses frontier matters comparable to rising enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and self sustaining enzymes for the synthesis and improvement of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and common product analogs
- Highlights the influence of biocatalysis on eco-friendly chemistry
- Contains various photos to demonstrate options and methods
Biocatalysis for the Pharmaceutical Industry is a necessary source for scientists, engineers, and R&D coverage makers within the effective chemical, pharmaceutical, and biotech industries. it's also a useful instrument for educational researchers and complex scholars of natural and fabrics synthesis, chemical biology, and medicinal chemistry.Content:
Chapter 1 Enzymes and Their man made purposes: an summary (pages 1–19): Junhua (Alex) Tao and Jian?He Xu
Chapter 2 Expression Hosts for Enzyme Discovery and creation (pages 21–44): Aleksandra Andryushkova and Anton Glieder
Chapter three Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin Zhao
Chapter four functions of response Engineering to business Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas Liese
Chapter five Chiral Synthesis of Pharmaceutical Intermediates utilizing Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang Lin
Chapter 6 increasing the Scope of Aldolases as instruments for natural Synthesis (pages 111–119): William A. Greenberg
Chapter 7 man made purposes of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling Hua
Chapter eight purposes of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimo
Chapter nine Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin Mayhew
Chapter 10 program of Whole?Cell Biotransformation within the Pharmaceutical (pages 213–227): family members Sing Lam
Chapter eleven Combinatorial Biosynthesis of Pharmaceutical traditional items (pages 229–245): Wen Liu and Yi Yu
Chapter 12 Metabolic Engineering for the improvement and production of prescribed drugs (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi Wang
Chapter thirteen Multimodular Synthases and assisting Enzymes for Chemical creation (pages 273–303): Michael Burkart and Junhua (Alex) Tao
Chapter 14 eco-friendly Chemistry with Biocatalysis for construction of prescribed drugs (pages 305–321): Oliver might
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Additional resources for Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing
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