Biocatalysis for the Pharmaceutical Industry: Discovery, by Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese

By Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese

Biocatalysis is swiftly evolving right into a key know-how for the invention and construction of chemical substances, in particular within the pharmaceutical undefined, the place excessive yielding chemo-, regio-, and enantioselective reactions are severe. Taking the newest breakthroughs in genomics and proteomics under consideration, Biocatalysis for the Pharmaceutical Industry concisely but comprehensively discusses the fashionable software of biocatalysis to drug discovery, improvement, and production. Written via a workforce of major specialists, the publication bargains deep perception into this leading edge box.

  • Covers quite a lot of themes in a scientific demeanour with an emphasis on business purposes
  • Provides a radical creation to the newest biocatalysts, sleek expression hosts, state of the art directed evolution, excessive throughput screening, and bioprocess engineering
  • Addresses frontier matters comparable to rising enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and self sustaining enzymes for the synthesis and improvement of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and common product analogs
  • Highlights the influence of biocatalysis on eco-friendly chemistry
  • Contains various photos to demonstrate options and methods

Biocatalysis for the Pharmaceutical Industry is a necessary source for scientists, engineers, and R&D coverage makers within the effective chemical, pharmaceutical, and biotech industries. it's also a useful instrument for educational researchers and complex scholars of natural and fabrics synthesis, chemical biology, and medicinal chemistry.Content:
Chapter 1 Enzymes and Their man made purposes: an summary (pages 1–19): Junhua (Alex) Tao and Jian?He Xu
Chapter 2 Expression Hosts for Enzyme Discovery and creation (pages 21–44): Aleksandra Andryushkova and Anton Glieder
Chapter three Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin Zhao
Chapter four functions of response Engineering to business Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas Liese
Chapter five Chiral Synthesis of Pharmaceutical Intermediates utilizing Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang Lin
Chapter 6 increasing the Scope of Aldolases as instruments for natural Synthesis (pages 111–119): William A. Greenberg
Chapter 7 man made purposes of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling Hua
Chapter eight purposes of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimo
Chapter nine Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin Mayhew
Chapter 10 program of Whole?Cell Biotransformation within the Pharmaceutical (pages 213–227): family members Sing Lam
Chapter eleven Combinatorial Biosynthesis of Pharmaceutical traditional items (pages 229–245): Wen Liu and Yi Yu
Chapter 12 Metabolic Engineering for the improvement and production of prescribed drugs (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi Wang
Chapter thirteen Multimodular Synthases and assisting Enzymes for Chemical creation (pages 273–303): Michael Burkart and Junhua (Alex) Tao
Chapter 14 eco-friendly Chemistry with Biocatalysis for construction of prescribed drugs (pages 305–321): Oliver might

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C. et al. (2007) Engineered alkane-hydroxylating cytochrome P450 (BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International Edition in English), 46 (44), 8414–8418. J. et al. (2007) Comparison of different strategies to reduce acetate formation in Escherichia coli. Biotechnology Progress, 23 (5), 1053–1063. , Nedal, A. et al. (2007) The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Pichia pastoris.

1). The location in the natural host also gives some indications which redox conditions are preferable for the target protein. Roughly, proteins can be divided into two groups: . proteins which do not require posttranslational modifications and special targeting; proteins which require posttranslational modifications to be active, such as the most prominent example – N-glycosylation. Glycosylation greatly affects folding [1], biological activity [2,3], functions [4], clearance from blood circulation [5] and antigenicity of the proteins [6].

Y. et al. (1999) Increased immunogenicity of tumor vaccines complexed with anti-Gal: studies in knockout mice for a1,3galactosyltransferase. Cancer Research, 59 (14), 3417–3423. J. et al. (2002) The effect of dissolved oxygen (DO) concentration on the glycosylation of recombinant protein produced by the insect cell-baculovirus expression system. Biotechnology and Bioengineering, 77 (2), 219–224. L. (2006) Cloning technologies for protein expression and purification. Current Opinion in Biotechnology, 17 (4), 359–366.

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