Biochemical and Pharmacological Roles of Adenosylmethionine by Vincenzo Zappia, Earl Usdin and Francesco Salvatore (Eds.)

By Vincenzo Zappia, Earl Usdin and Francesco Salvatore (Eds.)

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Additional info for Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System. Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978

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Jones and Carnegie found no evidence for the existence of two enzymes specific for the methylation of myelin protein and histone (11), but Miyake reported two forms of methylases from rat brain, one for myelin basic protein and the other for histone (12). The myelin protein methylating activity in the cell sap fraction was shown to increase during myélination, while histone methylase from the nuclear fraction was highest at birth with no correlation with the process of myelination. (13). Β. Encephalitogenic Myelin Basic Protein as a Endogenous Substrate The first evidence that one of the endogenous substrates for protein methylase I in the rat brain is the encephalitogenic basic protein of myelin sheath came from the sequence study of the protein.

These peaks are followed by rather rapid fall in the incorporation of methyl group upon continuous incubation at 37*. At the end of 2 hours incubation, about 3/4 of the previously incorporated methyl groups were lost. This is most likely due to a de-esterification reaction which was progressing simultaneously (see also Fig. 1). Therefore, methyl incorporation shown in Fig. , enzymatic esterification and chemical de-esterification, although interplay of these two re­ action mechanisms is not yet clear.

Paik As shown in Table 2, degree of esterification greatly depends on the polypeptide used for the reaction. 5 110 309 178 330 II Μ 30 τι II 60 II II are the best acceptors for the methylation. 8 That 3-lipotropin (3-LPH) was a good methyl acceptor and 3-endorphin (3-EP) was not suggests that the methyl acceptor portion of lipotropin is probably situated in the N-terminal segment of the mole­ cule (30). 1 mole % of methyl groups, the 3-subunit was almost devoid of the accepting activity. 6 mole % in­ corporation in the lutropin molecule were mostly due to the a-subunit, since both subunits have similar molecular weight (31).

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