Biotechnological Applications of the Yeast Yarrowia by Farshad Darvishi Harzevili

By Farshad Darvishi Harzevili

Due to its skill to degrade hydrophobic substrates hugely successfully, the non-conventional yeast Yarrowia lipolytica bargains a number of functions within the nutrients, feed, pharmaceutical, and high-quality chemistry industries, in addition to in environmental defense contexts similar to waste therapy and bioremediation.

The yeast breaks down hydrophobic substrates resembling n-alkanes, fatty acids, fat, and oils, yielding worthy biotechnological items reminiscent of natural acids, extracellular enzymes, aroma compounds, bioemulsifiers, polyols, single-cell proteins, and single-cell oils. extra, Y. lipolytica is an effective platform for the creation of varied heterologous proteins; greater than 100 heterologous proteins – together with these of viruses, micro organism and fungi, in addition to plant, animal and human proteins – have already been produced in Y. lipolytica. considering its genome has been sequenced, it really is now attainable to take advantage of new recombinant expertise and metabolic engineering which will enhance the metabolic pathways fascinated about the construction of fascinating metabolites and products.

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2004). A recombinant of the diploid strain Y. lipolytica was constructed with expression of POX2 gene and disruption of POX3 genes on two chromosomes, but without disruption of POX4 and POX5 genes. This mutant could be grown in the continuous fermentation of methyl ricinoleate and produced 4-fold c-decalactone compared with the wild-type strain. It could be concluded that the positive effect of Aox2 had a greater influence than negative action of Aox3 on the c-decalactone production (Guo et al.

It contains mainly lignocellulosic wastes with a mixture of carbohydrates and oil. POME also presents very high BOD and COD values of 246,000 and 11,000 mg/ L, respectively. The Y. lipolytica NCIM 3589 was used for treatment of POME without any addition of nutriment or dilution. The strain reduced the COD of the effluent by 95 % within 48 h. Treatment with a chemical coagulant further reduced the COD and a consortium developed from garden soil clarified the effluent and adjusted the pH to between 6 and 7.

The results showed that immobilized cells had high thermostability compared to that of free cells, and substrate concentration significantly affected degrading ability of immobilized cells (Wu et al. 2009). Y. lipolytica ACA-DC 50109 was cultivated on OMW enriched with commercial–industrial glucose. 9 g/L) was produced on OMW medium with initial sugar concentration of 65 g/L. OMW had a noteworthy stimulating effect on the production of citric acid, since both final citric acid concentration and conversion yield of citric acid produced per unit of sugar consumed were higher compared to the respective parameters obtained from trials without added OMW.

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