Burger's Medicinal Chemistry and Drug Discovery, Autocoids, by Donald J. Abraham

By Donald J. Abraham

This can be quantity four: Autocoids, Diagnostics, and medication from New Biology, of Burger's Medicinal Chemistry and Drug Discovery, sixth variation. This new quantity includes severe new chapters on Peptide and Protein Hormones, Peptide Neurotransmitters, and healing brokers, supplementations and SNPs: unmarried Nucleotide Polymorphisms and Pharmacogenomics.

To buy the complete 6 quantity set, please discuss with ISBN 0-471-37032-0.

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Additional resources for Burger's Medicinal Chemistry and Drug Discovery, Autocoids, Diagnostics, and Drugs from New Biology (Volume 4)

Example text

In the sulfonylureas glyburide, glipizide, and glimepiride, the carbon atom of the amido carbonyl group is a t the fourth position. Some benzoic acid derivatives like meglitinide (7), which has tolbutamide- like potency (107, 110, 1171, have a similar arrangement of the amido linker. 0. in rabbits (11611 also affords highly potent compounds. In this alternative, alkyl substitution of the carbon at the fourth position improves potency and activity resides in the S-enantiomers in both sulfonylurea and benzoic acid derivatives.

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Gottschalk, S. S. Sundseth, T. A. Mansfield, R. K. Ramachandran, T. M. Willson, and S. A. Kliewer, Endocrinology, 142,1269-1277 (2001). 139. M. Fuchtenbusch, E. Stand, and H. Schatz, Exp. Clin. Endocrinol. Diabetes, 108, 151-163 (2000). 140. A. J. Scheen, Drug S a f , 24,873-888 (2001). 141. P. J. Cox, D. A. Ryan, F. J. Hollis, A. Harris, A. K. Miller, M. Vousden, and H. Cowley, Drug Metab. , 28, 772-780 (2000). 142. S. J. Baldwin, S. E. Clarke, and R. J. Chenery, Br. J. Clin. , 48,424-432 (1999).

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