By James F. Holland M. D. (auth.), James F. Holland M. D., Myroslaw M. Hreshchyshyn M. D. (eds.)
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WYNN and DAVIES (1964) have described the ultrastructure of this same tumor strain. Electron microscopy revealed cells which resembled normal syncytiotrophoblast in that the cytoplasm contained abundant endo-cytoplasmic reticulum, ribosomes and distinctive Golgi bodies. Distinctly cytotrophoblastic cells were also identified. In addition a type of transitional cell was described with structural resemblance in some features to both cytotrophoblast and syncytiotrophoblast. Of major interest is the sustained hormonal activity of all of our tumor strains.
Age distribution in choriocarcinoma and parturient women Choriocarcinoma Parturient women No. No. 4 0 100 38 DONALD P. 8 years, the youngest patient being 17 and the oldest 50. 5 per cent of these 40 cases were 35 or more. Table I shows the distribution of cases according to the patent's age at the time of diagnosis of C. CHAN: nancies in the older age groups. 3. Fig. 1 a and Fig. 1 b show respectively the distribution of cases by gravidity order in the 40 cases of choriocarcinoma and in the 1,663 women who serve as controls.
When the metastasis is confined to the lungs, or vagina or broad ligament, and is recognized and treated early, recovery is possible. In my studies on 620 cases of hydatidiform mole admitted to the Philippine General Hospital from 1945 to 1964, I have found that advanced age and pulmonary tuberculosis predispose a mole to become malignant. When a hydatidiform mole develops in a woman past the age of 38 or when she has had a recent episode or presently is suffering from pulmonary tuberculosis, she should be followed for the possible later development of chorionic malignancy even though the biopsy of the mole is benign or Grade 1.