Chromatography of Pharmaceuticals. Natural, Synthetic, and by Satinder Ahuja

By Satinder Ahuja

content material: Chromatography and pharmaceutical research / Satinder Ahuja --
Chromatography and new drug improvement / Satinder Ahuja --
exchange options for research of prescribed drugs / John A. Adamovics and Kimberly Shields --
Ruggedness of impurity determinations in prescription drugs : high-performance liquid chromatography research with ultraviolet detection / M.P. Newton, John Mascho, and Randy J. Maddux --
High-performance liquid chromatography in pharmaceutical improvement of antibiotic items / L.J. Lorenz --
gasoline chromatography and pharmaceutical analyses / Harold M. McNair and Ketan M. Trivedi --
gasoline chromatography and mass spectrometry of Erythrina alkaloids from the foliage of genetic clones of 3 Erythrina species / Lori D. Payne and Joe P. Foley --
constructing stereoselective high-performance liquid chromatographic assays for pharmacokinetic reviews / Irving W. Wainer --
Direct enantiomeric separation and research of a few aromatase inhibitors on cellulose-based chiral desk bound stages / Hassan Y. Aboul-Enein --
Chromatographic research of host-cell protein impurities in prescription drugs derived from recombinant DNA / Donald O. O'Keefe and Mark L. Will --
Binding proteins in improvement of online postcolumn response detection structures for liquid chromatography / Minas S. Barbarakis and Leonidas G. Bachas --
selection of a brand new oral cephalosporin in organic fluids : liquid chromatographic, ultraviolet, and mass spectrometric tools / Hwai-Tzong Pan, Pramila Kumari, and Chin-Chung Lin --
medications and metabolites in organic fluids : computerized research by way of laboratory robotics / Linda A. Brunner --
Preparative separations of glycerophospholipids by means of high-performance liquid chromatography / J.V. Amari and P.R. Brown --
Small-molecule pharmaceutical separations via capillary electrophoresis : technique improvement and manipulation of selectivity / Michael E. Swartz and John VanAntwerp.

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Extra resources for Chromatography of Pharmaceuticals. Natural, Synthetic, and Recombinant Products

Sample text

Silica chromatogram of nadolol that has been spiked with several impurities. H Q-ÇH H CHCONHi NHo 2 N ^ Ο- \ ~H Y ^^ C u NH : o^" 2 N COOH COOH Cephalexin Cephradine HO-^ CH. ^— CHCONHi NH 2 H : o^ H : - CH n COOH Cefadroxil Figure 6. Structures of cephradine and related cephalosporins. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1992. 5 15 min. Figure 7. 7 min. 05% phosphoric acid. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1992. ch003 36 Fosinopril Sodium (S,R,S,S) 3 (S,R,S R) e t 1 (R,S) and (S,R) adds β Figure 8.

Varying the wavelengths -5 t o +5 nm r e s u l t e d i n changes i n the r e l a t i v e response f a c t o r s of up to 84% (Table I ) . Other parameters expected to p o s s i b l y change the UV c h a r a c t e r i s t i c s of the four compounds are pH, percent organic composition ( s o l v e n t strength), and i o n i c strength of the mobile phase. Changes i n r e l a t i v e response f a c t o r s up to 28, 15 and 13% r e s p e c t i v e l y were observed when these parameters were modified (Table I I ) .

AHUJA 26. 27. 28. ch002 29. 30. 31. 32. 33. 34. 35. 36. 37. Chromatography and New Drug Development 25 S. Ahuja, S. Shiromani, G. Thompson, and J. Smith, Personal Communication, March 2, 1984. S. Ahuja, G. Thompson, and J. Smith 1st International Symposium on Separation of Chiral Molecules, Paris, France, May 31-June 2, 1988. S. , 1991. G. Blaschke, H . P. Kraft, K. Fickentscher, and F. -Forsch. 29, 1640 (1979). "Top 200 Drugs in 1982", Pharmacy Times, p. 25 (April 1982). Y . Okamoto, CHEMTECH.

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