By Defang Ouyang, Sean C. Smith, Dennis Douroumis, Alfred Fahr, Juergen Siepmann, Martin J. Snowden, Vladimir Torchilin
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Additional info for Computational Pharmaceutics: Application of Molecular Modelling in Drug Delivery
Thermal calorimetric measurements on polymorphic transformations, heats of fusion and melting temperatures can be used to construct energy temperature diagrams for known polymorphs, to give the order of stability at 0 K for comparison with lattice energy rankings. Measured enthalpies suggest that lattice energy differences between observed polymorphs are small, usually of order of a few kJ mol−1. Various reviews of computational methods applied to solid form pharmaceutical modelling reveal that predicting the relative stability of known polymorphs is challenging [54, 55].
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