By Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth
Written through contributors of Pfizer international examine and improvement for chemists getting into the pharmaceutical undefined, this paintings profiles the synthesis of fourteen consultant pharmaceutical items to be able to display the multidisciplinary nature of the pastime. for every drug, they supply a ancient creation and the organic, pharmacological, pharmakinetic, and drug metabolism historical past prior to detailing the drug's synthesis.
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Extra info for Contemporary Drug Synthesis
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ISBN: 0-47 1 -2 1480-9 Chapter 3. H'K-ATPase Inhibitors: Esomeprazole (Nexium") 21 Chapter 3. H+/K+-ATPaseInhibitors: Esomeprazole (Nexium@) USAN: Omeprazole Trade Name. W. 345 21 USAN. W. 1 Introduction Hydrochloric acid (HCl), as the gastric acid, is a major constituent of the secretions of the gastrointestinal tract. It is essential to the food digestion process. However, excessive secretion of HCl will damage the mucosa and subsequently the submucosa, producing ulceration of the gastrointestinal tract, especially the stomach and duodenum.
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