Contrast Media in Practice by H. J. Maurer, W. Clauss, T. Gulbrandsen, P. Dawson (auth.),

By H. J. Maurer, W. Clauss, T. Gulbrandsen, P. Dawson (auth.), Dr. Peter Dawson, Dr. Wolfram Clauß (eds.)

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G. due to adverse publicity. The other methods listed are generally employed when further clarification of questions arising from the spontaneous adverse event or reaction monitoring is necessary. Clinical Documentation of the Tolerance, Safety and Efficacy 37 Interestingly, the incidence of eM adverse reactions in preregistration trials is 2-10 times higher than that recorded in PMS. The pattern of reaction is the same, so the difference probably reflects the greater scrutiny and vigilance in early clinical phases [2] compared with daily clinical routine.

These electrolytes are said to have a positive effect on the tolerance of the ionic CM.

2. A small proportion of the X-ray eM that is exclusively excreted by glomeruli is reabsorbed by the proximal renal tubules. 5 g I1kg) and iotrolan (6 g I1kg) indicate that the extreme vacuolation of the proximal renal tubular epithelium cells does not lead to structural changes in cell organelles. 1 have practically the same excretion kinetics and all are metabolically stable. Moreau et al. [35] have described changes in the context of water-soluble X-ray eM of vacuolation of the proximal renal tubular epithelium cells in renal biopsies of humans.

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