By Ping I. Lee and William R. Good (Eds.)
content material: review of controlled-release drug supply / Ping I. Lee and William R. stable --
Microstructural versions for diffusive delivery in porous polymers / W. Mark Saltzman, Stephen H. Pasternak, and Robert Langer --
Diffusion in heterogeneous media / Bret Berner, J.C. Keister, and Eugene R. Cooper --
Estimation of charges of drug diffusion in polymers / C.G. Pitt, A.L. Andrady, Y.T. Bao, and N.K.P. Samuel --
Interpretation of drug-release kinetics from hydrogel matrices when it comes to time-dependent diffusion coefficients / Ping I. Lee --
Physicochemical types for percutaneous absorption / J. Hadgraft and Richard H. man --
floor chemical research of polymeric drug supply platforms through static secondary ion mass spectrometry (SSIMS) and SIMS imaging / M.C. Davies and A. Brown --
more desirable strategy for measuring in vitro diffusion of substances via human dermis / L.R. Brown, J.F. Cline, C.L. Raleigh, and M.B. Henry --
Simplified process for measuring controlled-release kinetics / Charles G. Gebelein, Tahseen Mirza, and Robert R. Hartsough --
Thermally reversible gelation features : poly(oxyethylene)-poly(oxypropylene) block copolymer in aqueous resolution after publicity to high-energy irradiation / D. Attwood, C.J. Tait, and J.H. Collett --
unlock and behind schedule liberate of water-soluble medicinal drugs from polymer beads with low water swelling / Karl F. Mueller --
Morphine hydrogel suppositories : machine layout, scale-up, and review / Marion E. McNeill and Neil B. Graham --
Use of bioerodible polymers in self-regulated drug supply platforms / J. Heller, S.H. Pangburn, and D.W.H. Penhale --
Polysaccharides as drug companies : activation strategies and biodegradation reviews / Etienne Schacht, Filip Vandoorne, Joan Vermeersch, and Ruth Duncan --
Microspheres as controlled-release structures for parenteral and nasal management / S.S. Davis, L. Illum, D. Burgess, J. Ratcliffe, and S.N. generators --
improving drug unlock from polylactide microspheres through the use of base within the microencapsulation approach / Jones W. Fong, Hawkins V. Maulding, George E. Visscher, Josephine P. Nazareno, and Jane E. Pearson --
results of ethanol at the delivery of [beta]-estradiol in hairless mouse epidermis : comparability of experimental information with a brand new theoretical version / W.I. Higuchi, U.D. Rohr, S.A. Burton, P. Liu, J.L. Fox, A.H. Ghanem, H. Mahmoud, S. Borsadia, and William R. reliable --
Probing the constitution of stratum corneum at the molecular point / ok. Knutson, S.L. Krill, W.J. Lambert, and W.I. Higuchi --
New liposomal supply procedure for managed drug unlock / Victoria M. Knepp, Robert S. Hinz, Francis C. Szoka, Jr., and Richard H. man --
stronger absorption of ionizable medicines from topical dosage varieties / Tsuneji Nagai and Toyoaki Ishikura --
Transdermal drug supply approach with better epidermis permeability / Yei W. Chien and Chia-Shun Lee --
option to increase intranasal peptide supply / Lawrence S. Olanoff and Richard E. Gibson --
Transbuccal absorption of diclofenac sodium in a puppy version / C.D. Ebert, V.A. John, P.T. Beall, and K.A. Rosenzweig --
Constant-release diffusion platforms : cost keep an eye on via geometric configuration / K.G. Nelson, S.J. Smith, and R.M. Bennett --
Disposable controlled-release gadget for drug infusion / Paul Y. Wang, Mary C.Y. Lee, and will S.M. Smith.
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Extra resources for Controlled-Release Technology. Pharmaceutical Applications
A comparison of the experimental electrical values with the diffusion theory. W. ; ACS Symposium Series; American Chemical Washington. C. Society: 20036Washington, DC, 1987. 48 CONTROLLED-RELEASE TECHNOLOGY References 1. M. In "Diffusion in Polymers"; Crank, J . : Academic Press: New York, 1968: pp. 165-217. 2. ; J. Memb. Sci. 1983, 14, 139-145. ; J. Pharm. Sci. 1984, 73, 102-104. 4. ; J. Controlled Release. 1984, 1, 149-152. 5. ; J. Controlled Release. 1986, 3, 155-166. 6. C. Manuscript in preparation.
Tg = 2/3T (°K) m unsymmetrical polymers (6a) Tg = 1/2T (°K) m symmetrical polymers (6b) If information on Tg i s not available, the density can be used as an estimate of the free volume of the polymer. The lower the density, the greater the permeability. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. 21 G U T T A P E R C H A Do 7 ETHYLENE) 2 Figure 2. Relationship between activation energy of diffusion (E_), the relative size of the diffusing molecule, (dN /dX) and the glass transition temperature ( T ) of the polymer.
0 Si- 1 2 1 1 4 1—ι—|'"^ t τ 6 8 10 Figure 11. Ζ versus S for small A . The actual values are represented by the solid lines. Other symbols represent the lower and upper bounds of Z. (Reproduced with permission from Ref. 5. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. 46 CONTROLLED-RELEASE TECHNOLOGY C o n s e q u e n t l y , f i l m d i s c o n t i n u i t y e f f e c t s can be s i z e a b l e even a t s m a l l A^. A T i l m can appear c o m p l e t e l y c o a t e d even though the f l u x i s v i r t u a l l y u n a f f e c t e d i f S f o r the f i l m i s v e r y s m a l l .