DNA Damage Recognition by Wolfram Siede (Editor), Yoke Wah Kow (Editor), Paul W.

By Wolfram Siede (Editor), Yoke Wah Kow (Editor), Paul W. Doetsch (Editor)

Stands because the so much entire consultant to the subject—covering each crucial subject with regards to DNA harm id and service. masking a wide range of subject matters from micro organism to human cells, this e-book summarizes fresh advancements in DNA harm fix and popularity whereas delivering well timed reports at the molecular mechanisms hired by way of cells to differentiate among broken and undamaged websites and stimulate the proper fix pathways. in regards to the editors... WOLFRAM SIEDE is affiliate Professor, division of mobilephone Biology and Genetics, collage of North Texas healthiness technology heart, castle Worth.  He obtained the Ph.D. measure (1986) from Johann Wolfgang Goethe collage, Frankfurt Germany. YOKE WAH KOW is Professor, division of Radiation Oncology, Emory collage college of medication, Atlanta, Georgia.  He acquired the Ph.D. measure (1981) from Brandeis college, Waltham, Massachusetts. PAUL W. DOETSCH is Professor, Departments of Biochemistry, Radiation Oncology, and Hematology and Oncology, and affiliate Director for simple learn, Winship melanoma Institute, Emory collage college of drugs, Atlanta, Georgia.  He bought the Ph.D. measure (1982) from Temple college tuition of medication, Philadelphia, Pennsylvania.

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Proc Natl Acad Sci USA 2001; 98(1):37–41. 48. Stivers JT. 2-Aminopurine fluorescence studies of base stacking interactions at abasic sites in DNA: metal-ion and base sequence effects. Nucleic Acids Res 1998; 26(16): 3837–3844. 49. Varani G, McClain WH. The GU wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems. EMBO Rep 2000; 1(1):18–23. 50. Saparbaev M, Laval J. 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil–DNA glycosylase and human mismatch-specific thymine–DNA glycosylase.

Once the DNA is bent, the damaged base is now able to flip out of the DNA helix to form the catalytic complex. Sequences requiring more distortion energy will be less good UDG substrates, and therefore will be repaired less frequently. This schematic representation integrates DNA flexibility with the process of damage recognition and its efficient repair. ACKNOWLEDGMENTS This work was supported by PHS Grant CA 63317 and by training grants GM08553 and CA78207. REFERENCES 1. Krokan HE, Standal R, Slupphaug G.

The sequences that were used for the experimental part were taken from the work of Slupphaug et al. (17) and are shown below. They are named AUA and GUG to represent the surrounding bases in the sequence. P represents 2-aminopurine, which does not perturb the DNA structure and properties (44). For the computational simulations the sequence has been shortened by 4 base pairs on each side to be able to conduct nearly converged simulations. UDG efficiency on the AUA sequence was approximately 20-fold greater than on the GUG.

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