Drug Delivery Systems by Kewal K. Jain (auth.), Kewal K. Jain (eds.)

By Kewal K. Jain (auth.), Kewal K. Jain (eds.)

The box of drug improvement and therapeutics will be overwhelmingly encyclopedic and mammoth. In Drug supply Systems, Dr. Kewal Jain and a group of specialists opt for an important, state of the art applied sciences utilized in drug supply platforms bearing in mind major medicinal drugs, new applied sciences reminiscent of nanoparticles, and healing functions. The chapters current step by step laboratory protocols following the hugely profitable Methods in Molecular Biology™ sequence structure, providing without problems reproducible effects important for pharmaceutical physicians and scientists.

Concise and systematic, Drug supply Systems is a strong reference device for the loads of businesses constructing drug supply applied sciences all over the world.

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Development for a new formulation of a generic preparation has more potential of profit in relation to investment when compared with developing a new chemical entity. Reduction of financial risk. With large investments in R&D of biotechnology products, there is a considerable element of risk involved, and a number of biotechnology companies have failed. In contrast, development of drug delivery products requires only a fraction of capital investment and less time for approval. The use of already approved drugs takes away the element of risk involved in approval of the main ingredient of the DDS.

The two terms – pharmacogenetics and pharmacogenomics – are sometimes used synonymously but one must recognize the differences between the two. Various technologies enable the analysis of these complex multifactorial situations to obtain individual genotypic and gene expression information. These same tools are applicable to study the diversity of drug effects in different populations. Pharmacogenomics promises to enable the development of safer and more effective drugs by helping to design clinical trials such that nonresponders would be eliminated from the patient population and take the guesswork out of prescribing medications.

Multilamellar vesicles consist of several lipid layers separated from each other by a layer of aqueous solution. Lipid bilayers of liposomes are similar in structure to those found in living cell membranes and can carry lipophilic substances such as drugs within these layers in the same way as cell membranes. The pharmaceutical properties of the liposomes depend on the composition of the lipid bilayer and its permeability and fluidity. Cholesterol, an important constituent of many cell membranes, is frequently included in liposome formulations because it reduces the permeability and increases the stability of the phospholipid bilayers.

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