By Brian S. Fulton
With habit a key aim for drug discovery efforts, this e-book fills an incredible and well timed desire for medicinal chemists who have to comprehend complicated neuroscience matters. the writer illustrates medicinal chemistry's well-liked position in treating habit and covers particular medicinal drugs of abuse together with narcotics, stimulants, depressants, nicotine, and marijuana.
• Interprets complicated neuro- organic and pharmacological info, just like the drug-reward process, for medicinal chemists
• Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs
• Pulls jointly details at the many power drug ambitions for treating addiction
• Stresses particular medicinal chemistry difficulties while describing pharmacology trying out tools and drug development
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Additional resources for Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies
In other words, a glutaminergic neuron may not only contain receptors for glutamate. Drugs of abuse elicit their effects by binding to receptors and modulating neurotransmission. Likewise, drugs that treat psychiatric disorders also modulate neurotransmitter levels in the brain by binding to receptors. This modulation of neurotransmission can occur directly but drugs of abuse also do so by indirectly affecting the levels of one neurotransmitter by interacting first at a different neurotransmitter system.
43 Of the three, serotonin is unique in that the serotonin transporter is particularly selective and serotonin does not bind strongly to DAT and NET. As we can see from their structures, this can be rationalized as dopamine and norepinephrine differ in structure only by a benzylic hydroxyl group. 5 NEUROCIRCUITRY AND NEUROTRANSMITTERS IN ADDICTION Information flow throughout the CNS occurs via what is called the neurocircuitry of the brain. 44 A complexity of CNS drug discovery is that all mental illnesses appear to involve the disruption of at least one neurocircuit.
The mGlu receptors are also activated by the endogenous amino acids: aspartate, serine-O-phosphate, N-acetylaspartylglutamate, and cysteine sulfinic acid. 47 mGlu2 and mGlu3 Receptors The mGlu2 receptors are expressed only in neurons while the mGlu3 receptors are thought to be present in both neurons and glia cells; both receptors are located presynaptic and postsynaptic. An important feature of mGlu receptors is that they do not mediate fast excitatory transmission. Rather, they appear to have a modulatory effect on glutaminergic transmission.