Drug Discovery for the Treatment of Addiction : Medicinal by Brian S. Fulton

By Brian S. Fulton

With habit a key aim for drug discovery efforts, this e-book fills an incredible and well timed desire for medicinal chemists who have to comprehend complicated neuroscience matters. the writer illustrates medicinal chemistry's well-liked position in treating habit and covers particular medicinal drugs of abuse together with narcotics, stimulants, depressants, nicotine, and marijuana.

• Interprets complicated neuro- organic and pharmacological info, just like the drug-reward process, for medicinal chemists
• Emphasizes neurotransmitters and neurochemical mechanisms of addictive drugs
• Pulls jointly details at the many power drug ambitions for treating addiction
• Stresses particular medicinal chemistry difficulties while describing pharmacology trying out tools and drug development

Show description

Read Online or Download Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies PDF

Similar pharmacy books

Advanced Drug Design and Development: A Medicinal Chemistry Approach

The dep. of Pharmaceutical-Medicinal Chemistry, university of Pharmacy, Aristotelian collage of Thessaloniki, organizes, some other 12 months, a graduate seminar in complex medicinal chemistry, with overseas participation, in Thessaloniki. the aim of this seminar is to assist younger and bold pharmaceutical scientists during this box by means of updating their wisdom and informing them concerning the new traits in our technological know-how, in the course of the displays of popular invited audio system.

FASTtrack: Therapeutics

This can be a revision consultant for college kids supplying bullet issues of simple details on therapeutics. "FASTtrack" is a brand new sequence of fundamental revision courses created specifically. The content material of every name specializes in what pharmacy scholars actually need to grasp which will move assessments, delivering concise, bulleted info, key issues, advice and an all-important self-assessment part together with MCQs, case stories, pattern essay questions and labored examples.

Frequently Prescribed Medications

Often Prescribed drugs: medicinal drugs you must recognize is a pragmatic research software designed to teach and try scholars in regards to the medicinal drugs which are most typically utilized in perform, in addition to a precious reference on drug info for health and wellbeing pros. This accomplished source stories very important innovations concerning the use of particular medicinal drugs and gives transparent and succinct details for the medication which are regularly used in scientific perform, ambulatory perform, and health center perform, together with details on prescription, over the counter, and common items.

Pumps, channels, and transporters : methods of functional analysis

Describes experimental equipment for investigating the functionality of pumps, channels and transporters Covers new rising analytical tools used to review ion delivery membrane proteins similar to single-molecule spectroscopy information quite a lot of electrophysiological suggestions and spectroscopic tools used to research the functionality of ion channels, ion pumps and transporters Covers state-of-the paintings analytical ways to research ion pumps, channels, and transporters, and the place analytical chemistry could make additional contributions

Additional resources for Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies

Example text

In other words, a glutaminergic neuron may not only contain receptors for glutamate. Drugs of abuse elicit their effects by binding to receptors and modulating neurotransmission. Likewise, drugs that treat psychiatric disorders also modulate neurotransmitter levels in the brain by binding to receptors. This modulation of neurotransmission can occur directly but drugs of abuse also do so by indirectly affecting the levels of one neurotransmitter by interacting first at a different neurotransmitter system.

43 Of the three, serotonin is unique in that the serotonin transporter is particularly selective and serotonin does not bind strongly to DAT and NET. As we can see from their structures, this can be rationalized as dopamine and norepinephrine differ in structure only by a benzylic hydroxyl group. 5 NEUROCIRCUITRY AND NEUROTRANSMITTERS IN ADDICTION Information flow throughout the CNS occurs via what is called the neurocircuitry of the brain. 44 A complexity of CNS drug discovery is that all mental illnesses appear to involve the disruption of at least one neurocircuit.

The mGlu receptors are also activated by the endogenous amino acids: aspartate, serine-O-phosphate, N-acetylaspartylglutamate, and cysteine sulfinic acid. 47 mGlu2 and mGlu3 Receptors The mGlu2 receptors are expressed only in neurons while the mGlu3 receptors are thought to be present in both neurons and glia cells; both receptors are located presynaptic and postsynaptic. An important feature of mGlu receptors is that they do not mediate fast excitatory transmission. Rather, they appear to have a modulatory effect on glutaminergic transmission.

Download PDF sample

Rated 4.03 of 5 – based on 18 votes