Drug Metabolism Prediction by Johannes Kirchmair, Raimund Mannhold, Hugo Kubinyi, Gerd

By Johannes Kirchmair, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

The 1st expert reference in this hugely suitable subject, for drug builders, pharmacologists and toxicologists.
The authors offer greater than a scientific assessment of computational instruments and information bases for drug metabolism examine and their underlying rules. they target to exhibit their specialist wisdom distilled from a long time of expertise within the box. as well as the basics, computational techniques and their purposes, this quantity offers specialist bills of the most recent experimental tools for investigating drug metabolism in 4 devoted chapters. The authors speak about crucial caveats and customary blunders to think about while operating with experimental data.
Collating the information received during the last decade, this practice-oriented advisor provides equipment not just utilized in drug improvement, but additionally within the improvement and toxicological evaluate of cosmetics, sensible meals, agrochemicals, and ingredients for shopper items, making it a useful reference in numerous disciplines.

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Types Mechanisms 1. On-target ADRs Predictable in principle and generally dose dependent. Based on the pharmacology of the drug and its metabolite(s), often an exaggerated response or a response in a nontarget tissue 2. Off-target ADRs Predictable in principle and generally dose dependent. Resulting from the interaction of the drug or a metabolite with a nonintended target 3. ADRs involving reactive metabolites Predictable in principle and generally dose dependent. A major mechanism is covalent binding to macromolecules (adduct formation), resulting in cytotoxic responses, DNA damage, or hypersensitivity and immunological reactions.

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And Testa, B. (2009) Introduction: the how and why of References 26 27 28 29 30 31 32 33 34 35 36 bioavailability research, in Drug Bioavailability – Estimation of Solubility, Permeability, Absorption and Bioavailability, 2nd edn (eds H. van de Waterbeemd and B. Testa), Wiley-VCH Verlag GmbH, Weinheim, Germany, pp. 1–6. , Hanson, R. G. (2004) Discovering drugs though biological transformation: role of pharmacologically active metabolites in drug discovery. Journal of Medicinal Chemistry, 47, 4339–4351.

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