Pathology of a Black African Population by C. Isaacson (auth.)

By C. Isaacson (auth.)

Various nouns were utilized in the previous to explain the Black races of South Africa and those phrases should be used interchangeably within the textual content. They comprise "Bantu, African, Negro and Black". even though the at present instructed time period is that of "Blacks of South Africa", many articles were released within the scientific literature touching on Bantu, e. g. , "Bantu Siderosis", and different articles have seemed bearing on African, e. g. , "African Cardiomyopathy". the cloth for this learn used to be derived from the pathology laboratory at Barag­ wanath health facility (2,500 beds) which serves the city of Soweto, a Black city of ap­ prOximately 1 million population ten miles southwest of Johannesburg. There could, after all be differing occurrence premiums for varied illnesses in numerous elements of South Africa, even if the general pattern in all fairness uniform. No figures can be found as to how lengthy the population of Soweto have lived within the city or even if an important percentage­ age originated in rural parts. No comparisons have been for that reason tried among dis­ ease in rural and concrete parts. the cloth during this e-book offers primarily with pathol­ ogy within the city Black. This booklet isn't really a complete learn of pathology within the black neighborhood. simply definite points are handled, fairly these subject matters of in­ terest to the author.

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9). In the presence of hypertension, the heart shows left ventricular hypertrophy and the remaining organs show passive venous congestion if congestive cardiac failure has been present. In an occasional case the para aortic lymph nodes have been found to show a granulomatous reaction resembling tuberculosis, and it has been suggested that a hypersensitivity reaction to the tubercle bacillus in the para aortic lymph nodes may set up a reactive endarteritis of the vasa vasorum (Isaacson and Shnier 1961).

The mechanism is obscure. Pathological Findings in Iron Overload Excellent descriptions of the pathology of siderosis in Blacks are to be found in the literature (Higginson et al. 1953; Wainwright 1957), and the findings will be freely quoted. 49 Fig. 3. Typical micronodular cirrhosis with iron overload . The nodules are small and do not generally exceed 3 mm in diameter The description which follows applies to the majority of subjects with iron overload, and particularly to those without cirrhosis.

Jones (1962) described irreversible shock in hameochromatosis, and shock is fairly well recognized complication of this disease. In the cases described by Buchanan (1971), all but one had a very high serum iron and acute liver cell necrosis. The degree of shock and liver cell necrosis correlated well with the height of the serum iron. Buchanan feels that the mechanism of shock may not be the conventionally accepted one of massive release of ferritin into the circulation from necrotic liver cells causing vasodilatation, but that the shock in patients with excessive iron stores is a septic shock due to gram negative bacteraemia.

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